PF-06446846

SKU: orb1298749

Description

PF 06446846 is a highly potent and selective small molecule inhibitor of PCSK9. It is a valuable research tool for studying PCSK9's role in cholesterol metabolism and has demonstrated efficacy in both in vitro assays and in vivo models of dyslipidemia.

Key Properties

• CAS Number: 1632250-49-7
• MW: 433.89
• Purity: 99.4%
• Formula: C₂₂H₂₀ClN₇O
• SMILES: N(C(=O)C1=CC=C(C=C1)N2C=3C(N=N2)=CC=CN3)(C4=C(Cl)C=CC=N4)[C@@H]5CCCNC5
• Target: Others
• Solubility: DMSO:4.34 mg/mL (10 mM)

Bioactivity

• In Vivo:
  PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing. PF-06446846 is highly selective for the inhibition of PCSK9 translation. The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Serine endopeptidases, Ser/Thr Protease, Selective, Serine proteases, PF 06446846, Threonine proteases, PF06446846, PF-06446846, Rat bone marrow, 80S ribosome, inhibit, Inhibitor, PCSK9, Huh7

Compound Identifiers

PubChem CID

86271238