PF-06273340

SKU: orb1706029

Description

PF-06273340 is a potent, selective, and peripherally restricted pan-Trk inhibitor with single-digit nM IC50 values against TrkA, TrkB, and TrkC. Its pharmacokinetic profile, characterized by low hepatic metabolism, active efflux transport, and moderate permeability, supports its utility in preclinical research for investigating peripheral Trk-mediated pathways in pain and oncology models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1402438-74-7
• MW: 479.92
• Purity: 98.00% (May vary between batches)
• Formula: C₂₃H₂₂ClN₇O₃
• SMILES: C(=O)(C=1C=2C(N(C(CO)(C)C)C1)=NC(N)=NC2)C=3C=C(NC(CC4=CC=C(Cl)C=N4)=O)C=NC3
• Target: Trk receptor
• Solubility: Ethanol:1 mg/mL (2.08 mM);DMSO:90 mg/mL (187.53 mM);H2O:Insoluble

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF 6273340, PF 06273340, PF06273340, PF-06273340, PF6273340, PF-6273340, Trkreceptor, Tropomyosin related kinase receptor, Trk Receptor, Trk receptor, TrkC, TrkB, TrkA, inhibit, Inhibitor

Compound Identifiers

PubChem CID

66571548