PF-04995274

SKU: orb1307903

Description

PF-04995274

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1331782-27-4
• MW: 432.51
• Purity: 99.52% (May vary between batches)
• Formula: C₂₃H₃₂N₂O₆
• SMILES: OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1
• Target: 5-HT Receptor
• Solubility: DMSO:100 mg/mL (231.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.25 mM)

Bioactivity

• In Vivo:
  PF-04995274 (3-10 mg/kg; intravenous injection; for 17 days; male 129S6/SvEv mice) treatment demonstrates prophylactic efficacy by reducing learned fear and decreasing stress-induced depressive-like behavior.
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• In Vitro:
  PF-04995274 shows Ki values of 0.36 nM, 0.46 nM, 0.15 nM, 0.32 nM and 0.3nM for human 5-HT4A/4B/4D/4E and rat 5-HT4S, respectively. PF-04995274 displays EC50 values of 0.47 nM, 0.36 nM, 0.37 nM, 0.26 nM, 0.59 nM, 0.65 nM and 0.62 nM for human 5-HT4A/4B/4D/4E and rat 5-HT4S/4L/4E, respectively .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

behavior, 5HT Receptor, 5HTReceptor, 5-HT4 receptor, 5-HT4, 5-hydroxytryptamine Receptor, Alzheimer′s disease, 5-HT Receptor, depressive-like, inhibit, Inhibitor, PF 04995274, PF04995274, PF-04995274, Serotonin Receptor, Stress-induced

Compound Identifiers

PubChem CID

53354764