PF-04418948

SKU: orb1304338

Description

PF-04418948 is a highly selective and potent antagonist of the EP2 receptor (IC50 = 16 nM), demonstrating over 2000-fold selectivity against related prostanoid receptors. It effectively inhibits PGE2-induced cAMP signaling in vitro and reverses PGE2-mediated tracheal relaxation ex vivo (IC50 = 2.7 nM), making it a valuable tool for researching EP2 function in inflammation, smooth muscle physiology, and related disease models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1078166-57-0
• MW: 409.41
• Purity: 98.67%
• Formula: C₂₃H₂₀FNO₅
• SMILES: COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1
• Target: Prostaglandin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.89 mM);DMSO:45 mg/mL (109.91 mM)

Bioactivity

• Target IC50:
  EP2 receptor:16 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CHO, inhibit, Inhibitor, orally activity, PF 04418948, PF04418948, PF-04418948, PGE2, ProstaglandinReceptor, Prostaglandin Receptor

Compound Identifiers

PubChem CID

25114442