PF-04418948

• Catalog Number: orb1304338
• Category: Small Molecules
• Description: PF-04418948
• CAS Number: 1078166-57-0
• Purity: 99.45%
• MW: 409.41
• SMILES: C(OC1=CC2=C(C=C1)C=C(OC)C=C2)C3(C(O)=O)CN(C(=O)C4=CC=C(F)C=C4)C3
• Formula: C₂₃H₂₀FNO₅
• Biological Activity: PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits < 30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
• Note: For research use only
• Expiration Date: 12 months from date of receipt.