Penicillin V potassium salt

SKU: orb1226534

Description

Penicillin V potassium is a broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.(In Vitro):Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L.Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile, with a MIC90 of 8 mg/L.Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with a MIC of 0.016 mg/L.(In Vivo):Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle.Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats.Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L h).

Key Properties

• CAS Number: 132-98-9
• MW: 388.48
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇KN₂O₅S
• SMILES: O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(COC3=CC=CC=C3)=O)N1C2=O)[O-].[K+]
• Target: Others
• Solubility: Soluble in Water

Bioactivity

• In Vivo:
  Penicillin V (0.063-0.25 mg/kg; a single s. c.) inhibits the outgrowth of S. aureus in mice thigh muscle. Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats. Penicillin V (2 mg/kg; a single s. c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L h). Animal model: Specific pathogen free (SPF) male Swiss mice (20-25 g) are inoculated S. aureus. Dosage: 0.063, 0.13, 0.25 mg/kg. Administration: A single s. c. Result: Decreased the number of CFU (1.34×107 counts/mL) compared to controls (3.5×107 counts/mL) at the dose of 0.25 mg/kg.
• In Vitro:
  Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L. Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile, with a MIC90 of 8 mg/L. Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with a MIC of 0.016 mg/L.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phenoxymethylpenicillin

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