PD173074

SKU: orb1305225

Description

PD173074

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 219580-11-7
• MW: 523.67
• Purity: 98.21%
• Formula: C₂₈H₄₁N₇O₃
• SMILES: CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
• Target: VEGFR,Src,FGFR,Apoptosis,IGF-1R,EGFR
• Solubility: Ethanol:52.4 mg/mL (100.06 mM);DMSO:125 mg/mL (238.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.82 mM)

Bioactivity

• Target IC50:
  VEGFR2:100 nM-200 nM|FGFR1:25 nM
• In Vivo:
  PD173074 dose-dependently inhibite the autophosphorylation of VEGFR2 IC50 100-200 nM) and FGFR1 IC50 1-5 nM). PD173074 dose-dependently inhibited FGF-2-promoted granule neuron survival IC50 12 nM), which was more than 1,000-fold higher than SU 5402 activity. PD173074 specifically inhibited FGF-2-mediated cell proliferation, differentiation and MAPK activation in oligodendrocyte lineage cells.PD173074 was an ATP-competitive inhibitor of FGFR1 (Ki: 40 nM).PD173074 also dose-dependently and potently inhibite the autophosphorylation of FGFR3 IC50 5 nM). In multiple myeloma cell lines, PD173074 was active against wild-type and FGFR3 mutant types.PD173074 caused a significant decrease in the viability of FGFR3-expressing KMS11 and KMS18 cells IC50 20 nM).
• In Vitro:
  PD173074 dose-dependently inhibite the autophosphorylation of VEGFR2 IC50 100-200 nM) and FGFR1 IC50 1-5 nM). PD173074 dose-dependently inhibited FGF-2-promoted granule neuron survival IC50 12 nM), which was more than 1,000-fold higher than SU 5402 activity. PD173074 specifically inhibited FGF-2-mediated cell proliferation, differentiation and MAPK activation in oligodendrocyte lineage cells.PD173074 was an ATP-competitive inhibitor of FGFR1 (Ki: 40 nM).PD173074 also dose-dependently and potently inhibite the autophosphorylation of FGFR3 IC50 5 nM). In multiple myeloma cell lines, PD173074 was active against wild-type and FGFR3 mutant types.PD173074 caused a significant decrease in the viability of FGFR3-expressing KMS11 and KMS18 cells IC50 20 nM).
• Cell Research:
  Cells are incubated with increasing concentration of PD173074 in the presence of aFGF/heparin for 48 hours the percentage of viable cells is determined by MTT.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

c-Src, Apoptosis, PD173074, PD-173074, PD 173074, inhibit, Inhibitor, IGF1R, Insulin Receptor, EGFR, FGFR1, FGFR, Fibroblast growth factor receptor, VEGFR2, VEGFR, Vascular endothelial growth factor receptor

Compound Identifiers

PubChem CID

1401