PD-L1Pep-2

• Catalog Number: orb1479255
• Category: Proteins
• Description: Binds to PD-L1; Peptides.
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 860.48 Da
• Formula: C₃₃H₆₄N₁₆O₉S
• Structure: H-Cys-Val-Arg-Ala-Arg-Thr-Arg-OH
• Solubility (25°C): Soluble in water
• Protein Sequence: CVRARTR
• Storage: Store dry, frozen and in the dark
• Alternative names: CVRARTR, PD-L1-blocking peptide, PD-L1Pep-2PP380
• Background: PD-L1Pep-2 was identified from a phage-displayed library for peptides that selectively bind to PD-L1-overexpressing cells. PD-L1Pep-2 has a binding affinity of 281 nM, and preferentially binds to high PD-L1-expressing cells over low PD-L1-expressing cells, binding further enhanced by interferon-γ, an inducer of PD-L1 expression. In animal models, intravenously injected PD-L1Pep-2 efficiently targets tumour tissues, inhibits tumour growth, and increases the CD8+/FoxP3+ ratio in mice. PD-L1Pep-2 in combination with doxorubicin inhibits tumour growth more efficiently than doxorubicin alone. PD-L1Pep-2 blockade of PD-L1 reinvigorates T-cell activity and inhibits tumour growth by enhancing anti-tumour immunity.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.