PC786

SKU: orb1706843

Description

PC786 is a highly potent and selective non-nucleoside inhibitor of the RSV L-protein polymerase, designed for inhalation therapy. It demonstrates potent antiviral activity against RSV-A and RSV-B subtypes in vitro and inhibits the viral RNA-dependent RNA polymerase (RdRp), supporting its investigation in respiratory syncytial virus research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1902114-15-1
• MW: 715.84
• Purity: 99.26%
• Formula: C₄₁H₃₈FN₅O₄S
• SMILES: O=C(NC=1C(F)=CC=CC1C)C=2SC=3C=4C=CC=CC4N(C(=O)C5=CC=C(C=C5)NC(=O)C6=CC(=CN=C6N7CC8(C7)CCOCC8)C)CCC3C2
• Target: RSV
• Solubility: 10% DMSO+90% Corn Oil:4 mg/mL (5.59 mM);DMSO:120 mg/mL (167.64 mM)

Bioactivity

• Target IC50:
  RSV B:1.3–50.6 nM|RdRp (RSV, minigenome assay in HEp-2 cells):0.5 nM|RSV A:<0.09–0.71 nM|RdRp (RSV, cell-free enzyme assay):14.11 μM
• In Vivo:
  Treatment with PC786 (either intratracheal or intranasal; Once-daily on days-1 to 3), is found to inhibit viral loads in the lungs of RSV A2-infected BALB/c mice. The viral load is below the level of detection when the drug is given at 2 mg/mL (40 μg/mouse [approximately 1.6 mg/kg of body weight] for i.t. treatment, or 80 μg/mouse [approximately 3.2 mg/kg] for i.n. treatment).
• In Vitro:
  PC786 exhibits strong antiviral activity against RSV-A (IC₅₀: <0.09–0.71 nM) and RSV-B (IC₅₀: 1.3–50.6 nM) in HEp-2 cells, with no detectable cytotoxicity. PCR analysis confirmed inhibition of RSV replication, and PC786 potently inhibited RSV RNA-dependent RNA polymerase (RdRp) activity in both a cell-free enzyme assay (IC₅₀: 2.1 nM) and a minigenome assay in HEp-2 cells (IC₅₀: 0.5 nM).

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RSV-A, RSV-B, PC786, PC-786, PC 786

Compound Identifiers

PubChem CID

121276461