PBD-150

SKU: orb1299395

Description

PBD-150 is a potent small molecule inhibitor of the human glutaminyl cyclase (hQC) Y115E-Y117E mutant, exhibiting an inhibition constant (Ki) of 490 nM. This compound is a valuable research tool for investigating hQC's role in vitro, particularly in studies related to neurodegenerative conditions where QC activity is implicated.

Research Area

Neuroscience

Key Properties

• CAS Number: 790663-33-1
• MW: 320.4
• Purity: >98%
• Formula: C₁₅H₂₀N₄O₂S
• SMILES: COc1ccc(NC(=S)NCCCn2ccnc2)cc1OC
• Target: Beta Amyloid,Glutaminyl Cyclase
• Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)

Bioactivity

• In Vivo:
  A glutaminyl cyclase (QC) inhibitor, PBD150, was shown to be able to reduce the deposition of pyroglutamate-modified amyloid-β peptides in brain of transgenic mouse models of Alzheimer disease, leading to a significant improvement of learning and memory in those transgenic animals.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, BetaAmyloid, bAmyloid, b Amyloid, Amyloid-β, Abeta, Alzheimer, glutaminyl cyclase (hQC) Y115E-Y117E, PBD 150, PBD150, PBD-150, Inhibitor, inhibit, βAmyloid, β Amyloid, β-amyloid peptide

Compound Identifiers

PubChem CID

6539196