Patamostat mesylate

SKU: orb1691948

Description

Patamostat mesylate (E-3123) is an HDAC inhibitor that induces histone and tubulin acetylation, leading to cell cycle arrest and apoptosis in tumor cells. It has demonstrated antitumor activity in research models, including studies focused on multiple myeloma, both in vitro and in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 114568-32-0
• MW: 508.57
• Purity: 99.77% (May vary between batches)
• Formula: C₂₁H₂₄N₄O₇S₂
• SMILES: O=C(OC1=CC=C(SCCN2C(=O)CCC2=O)C=C1)C3=CC=C(C=C3)NC(=N)N.O=S(=O)(O)C
• Target: Apoptosis,HDAC,Serine Protease

Bioactivity

• Target IC50:
  plasmin:950 nM|trypsin:39 nM|thrombin:1.9 μM
• In Vivo:
  In male Wistar rats weighing approximately 350 g, Patamostat mesylate (2 mg/kg; continuous intravenous infusion for 1 hour) significantly improved the survival rate.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3123 mesylate, E-3123 mesylate, E 3123 mesylate, Apoptosis, HDAC

Compound Identifiers

PubChem CID

6918009