PARP1-IN-12

SKU: orb1744490

Description

PARP1-IN-12 is a highly potent PARP1 inhibitor (IC50 = 2.99 nM) with robust antiproliferative activity. It induces apoptosis, G2/M phase cell cycle arrest, and promotes DNA double-strand breaks in BRCA-deficient cells, making it a valuable tool for oncology research in both in vitro and in vivo models of homologous recombination deficiency.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• MW: 741.93
• Formula: C₄₃H₅₆FN₅O₅
• SMILES: C[C@H]1CCC[C@@]2(C)C1=CC3C(OC(C3CNCCCCCCCC(N4CCN(C(C5=C(F)C=CC(CC6=NNC(C7C6C=CC=C7)=O)=C5)=O)CC4)=O)=O)C2
• Target: Apoptosis,Others,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164887535