PAMP 20 (human)

• Catalog Number: orb1140595
• Category: Proteins
• Description: Endogenous MRGPRX2 agonist; Peptides.
• CAS Number: 150238-87-2
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2460.87 Da
• Formula: C₁₁₂H₁₇₈N₃₆O₂₇
• Structure: H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
• Solubility (25°C): Soluble to 1 mg/ml in water
• Protein Sequence: ARLDVASEFRKKWNKWALSR-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: 150238-87-2, ARLDVASEFRKKWNKWALSR, ARLDVASEFRKKWNK
• Background: PAMP 20 (human) is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 251 nM. PAMP 20, or proadrenomedullin N-terminal 20 peptide, is liberated from proadrenomedullin by proteolytic cleavage and is a potent hypotensive and catecholamine release inhibitory peptide. PAMP 20 (human) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.