Palonosetron hydrochloride

SKU: orb1309576

Description

Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist utilized to prevent chemotherapy-induced nausea and vomiting. It is widely employed in both in vitro binding studies and in vivo animal models to investigate antiemetic mechanisms and efficacy.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 135729-62-3
• MW: 332.87
• Purity: 99.97%
• Formula: C₁₉H₂₄N₂O·HCl
• SMILES: Cl.O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
• Target: 5-HT Receptor,Anti-infection
• Solubility: H2O:100 mg/mL (300.42 mM);DMSO:3.33 mg/mL (10 mM)

Bioactivity

• In Vivo:
  Palonosetron exhibits a longer plasma half-life of approximately 40 hours compared to other antagonists in its class (ondansetron, 4 hours; tropisetron, 7.3 hours; dolasetron, 7.5 hours; ranisetron, 8.9 hours). Additionally, it demonstrates a hundredfold greater binding affinity to the 5-HT3 receptor, with a pKi of 10.5, which is significantly higher than that of granisetron (pKi 8.91), tropisetron (pKi 8.81), ondansetron (pKi 8.39), and dolasetron (pKi 7.6).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RS 25259, RS-25259-197, Palonosetron HCl, 5-HT Receptor, 5HT Receptor, 5HTReceptor, 5-HT

Compound Identifiers

PubChem CID

6918303