p-MPPI hydrochloride

SKU: orb1307918

Description

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist. It exhibits antidepressant and anxiolytic-like properties in animal models and is used in neuroscience research to study serotonin receptor function in both in vitro and in vivo experimental systems.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 220643-77-6
• MW: 578.87
• Purity: 99.95%
• Formula: C₂₅H₂₈ClIN₄O₂
• SMILES: Cl.COc1ccccc1N1CCN(CCN(C(=O)c2ccc(I)cc2)c2ccccn2)CC1
• Target: 5-HT Receptor
• Solubility: DMSO:27.5 mg/mL (47.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.73 mM)

Bioactivity

• In Vivo:
  pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.)) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.)) reduced the effect of 8-OH-DPAT on waking and REM sleep. Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture. No overt behavioural change was produced by p-MPPI alone. Thus, p-MPPI behaved as a true 5-HT(1A) antagonist.
• Animal Research:
  Animal Model:Adult male Swiss Webster mice (aged 8-9 weeks). Dosage:0.5, 1.5, 4.5 mg/kg. Administration:i.p.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-hydroxytryptamine Receptor, 5HTReceptor, affinity, 5-HT1A Receptor, 5-HT1A, 5HT Receptor, 5-HT Receptor, antidepressant-like, anxiety, disorders, Inhibitor, ligand, inhibit, sleep, Serotonin Receptor, p MPPI hydrochloride, pMPPI hydrochloride, p-MPPI Hydrochloride, p-MPPI, selective

Compound Identifiers

PubChem CID

11957651