Oxychlororaphine

SKU: orb1940323

Description

Oxychlororaphine inhibits strongly the growth of Streptomyces sp. 441.

Key Properties

• CAS Number: 550-89-0
• MW: 223.235
• Purity: >98% (HPLC)
• Formula: C₁₃H₉N₃O
• SMILES: NC(=O)c1cccc2nc3ccccc3nc12
• Target: Antibacterial
• Solubility: In Vitro: DMSO : 10 mg/mL (44.80 mM)

Bioactivity

• In Vitro:
  Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM. Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein. Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase. Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP. Cell Viability Assay Cell line: A549, HeLa, and SW480 cancer cell lines. Concentration: 1, 2, 4, 8, 16, 32, 64, 128, and 256 μM. Incubation time: 24 hours. Result: Inhibited cell proliferative in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

phenazine-1-carboxamide

Quick Database Links

Gene Symbol

Antibacterial