Oxybutynin hydrochloride

SKU: orb1226166

Description

Oxybutynin is also a possible treatment of hyperhidrosis (hyper-active sweating) .(In Vitro):Oxybutynin chloride (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells.\n(In Vivo):Oxybutynin chloride (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1508-65-2
• MW: 393.96
• Purity: >98% (HPLC)
• Formula: C₂₂H₃₂ClNO₃
• SMILES: O=C(OCC#CCN(CC)CC)C(O)(C1CCCCC1)C2=CC=CC=C2.[H]Cl
• Target: AChR
• Solubility: Ethanol: 79 mg/mL (200.53 mM); Water: 4 mg/mL (10.15 mM); DMSO: 79 mg/mL (200.53 mM)

Bioactivity

• In Vivo:
  Oxybutynin chloride (27.2 mg/kg; p.o. ; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in Kd values for specific [3H]N-methylscopolamine binding 0.5 and 2 h later. Animal model: Male ddY strain mice (9 to 13-week-old). Dosage: 27.2 mg/kg (76.1 μmol/kg). Administration: Oral administration; single. Result: Significant increased Kd values for specific [3H]NMS binding in mouse bladder with values of 54.7% and 40.6% when at 0.5 and 2 hours, respectively. Significant increased Kd values for specific [3H]NMS binding in mouse cerebral cortex with values of 120% and 71.2% when at 0.5 and 2 hours, respectively.
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• In Vitro:
  Oxybutynin chloride (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells. Cell Viability Assay Cell line: Coronary arterial smooth muscle cells (from Male New Zealand White rabbits). Concentration: 10 μM. Incubation time: 200 ms. Result: Rapidly inhibited the Kv current within 2 min and reduced the Kv current by 44% at +60 Mv. Inhibited the Kv current by changing the gating properties of Kv channels. Cell Viability Assay Cell line: Coronary arterial smooth muscle cells (from male New Zealand White rabbits). Concentration: 0.1, 0.3, 1, 3, 10, 30, 100 μM Incubation time: 200 ms. Result: Reduced the Kv current amplitude in a concentration-dependent manner, with an IC50 value of 11.51 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MJ4309-1

Quick Database Links

Gene Symbol

AChR