Osilodrostat

SKU: orb1221655

Description

Osilodrostat (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).

Key Properties

• CAS Number: 928134-65-0
• MW: 227.24
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₀FN₃
• SMILES: Fc1cc(ccc1[C@H]1CCc2cncn12)C#N
• Target: MAO
• Solubility: DMSO : ≥ 83.3 mg/mL; 366.57 mM

Bioactivity

• In Vivo:
  Animal model: Male Ang-II-and ACTH-stimulated Sprague Dawley rats. Dosage: 0.1, 0.3, 1 and 3 mg/kg (Ang-II-stimulated rats) and 1, 3, 10, 30 and 100 mg/kg (ACTH-stimulated rats). Administration: Oral administration; once. Result: Inhibited the increase in plasma aldosterone concentrations stimulated by Ang II or ACTH in a dose-dependent manner. Animal model: dTG rats. Dosage: 3, 10, 30 and 100 mg/kg. Administration: Oral administration; daily, for 52 weeks. Result: Increased fractional LV (systolic and diastolic) shortening, normalized LV isovolumic relaxation time to RR (IVRT/RR) ratio and myocardial cell size and reduced LV weight in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LCI699

Quick Database Links

Gene Symbol

MAO