Orientin

SKU: orb1222416

Description

Orientin may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.

Key Properties

• CAS Number: 28608-75-5
• MW: 448.38
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₀O₁₁
• SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4C(C(C(C(O4)CO)O)O)O)O)O
• Target: COX
• Solubility: In Vitro: DMSO : 31.25 mg/mL (69.70 mM)

Bioactivity

• In Vivo:
  Animal model: PCA mouse model. Dosage: 0.1–10 mg/kg. Administration: Oral gavage (p.o.); Euthanized mouse after 1 h. Result: Significantly suppressed PCA reactions in PCA mouse model. Animal model: SNL rat model. Dosage: 10, 20, 40 mg/kg. Administration: Intraperitoneal injection (i.p.); Once daily for 12 days. Result: Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model. Decreased the levels of IL-6, IL-1β and TNF-α. Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA.
• In Vitro:
  Cell Viability Assay Cell line: RBL-2H3, mBMMCs, and RPMCs. Concentration: 0.01-100 μM Incubation time: 8 h. Result: Significantly suppressed the levels of histamine and β-hexosaminidase in RBL-2H3, mBMMCs, and RPMCs cells. Inhibited the intracellular calcium levels in RBL-2H3, mBMMCs, and RPMCs cells. Markedly inhibited the pro-inflammatory cytokines expression and secretion in RBL-2H3 cells. Inhibited phosphorylation in RBL-2H3 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Orientin | Lutexin

Quick Database Links

Gene Symbol

COX