Org 274179-0

SKU: orb2945711

Description

Org 274179-0 is a potent nanomolar allosteric antagonist of the TSH receptor, fully blocking TSH and TSI-induced signaling while largely preserving TSH efficacy. It is a valuable research tool for in vitro and in vivo studies of Graves' disease pathophysiology and receptor mechanism.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1421683-12-6
• MW: 480.521
• Formula: C₂₈H₂₇F₃N₂O₂
• SMILES: C[C@@]1(C=2C(N(C(C)=O)CC1)=CC=C(NC(CCC3=CC(C(F)(F)F)=CC=C3)=O)C2)C4=CC=CC=C4
• Target: TSH Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170898506