OMDM-1

SKU: orb1309300

Description

OMDM-1 is a potent and selective inhibitor of anandamide cellular uptake (ACU) with a Ki of 2.4 µM. This metabolically stable compound is a valuable research tool for investigating the endocannabinoid system in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 616884-62-9
• MW: 431.65
• Purity: 99.57%
• Formula: C₂₇H₄₅NO₃
• SMILES: C([C@H](NC(CCCCCCC/C=C\CCCCCCCC)=O)CO)C1=CC=C(O)C=C1
• Target: Endogenous Metabolite
• Solubility: DMSO:55 mg/mL (127.42 mM);Ethanol:30 mg/mL (69.5 mM);dimethyl formamide:30 mg/mL (69.5 mM)

Bioactivity

• Target IC50:
  Anandamide cellular uptake:2.4 μM(Ki)
• In Vitro:
  OMDM-1 is anovel potent and selective inhibitors of ACU and one "hybrid" agonist of CB(1) and VR1 receptors (OMDM-6). Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.The (R)- and, particularly, the (S)-1'-(4-hydroxybenzyl) derivatives of N-oleoylethanolamine and AEA (OMDM-1, OMDM-2, OMDM-3, and OMDM-4) inhibited to a varied extent ACU in RBL-2H3 cells (K(i) ranging between 2.4 and 17.7 micro M), the oleoyl analogues (OMDM-1 and OMDM-2, K(i) 2.4 and 3.0 micro M, respectively) being 6- to 7-fold more potent than the arachidonoyl analogues (OMDM-3 and OMDM-4). .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RBL-2H3, receptor, type, VR1, uptake, vanilloid, (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide, acids, anandamide cellular uptake, cannabinoid, cells, CB1, CB2, OMDM 1, OMDM1, OMDM-1, inhibit, EndogenousMetabolite, Endogenous Metabolite, FAAH, fatty, Inhibitor

Compound Identifiers

PubChem CID

10410511