Olmesartan medoxomil

SKU: orb1226258

Description

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Hypertension Approved(In Vitro):Inhibition of Arachidonic acid (AA) metabolism by angiotensin II receptor blockers (ARBs) is detected in a concentration-dependent manner with IC50 of Olmesartan (66.2 μM). Olmesartan medoxomil (OLM) is a potent and selective angiotensin AT1 receptor blocker.(In Vivo):The efficacy of Olmesartan (20 mg/kg) studied in db/db diabetic mice for a period of 12 weeks starting from week 10 to 12 of age. The db/db mice have 11.7 fold increased albuminuria in comparison to control mice at week 22 to 24 of age. Twelve weeks Olmesartan administration significantly reduces albuminuria in db/db mice by 77% as compared with placebo treated db/db mice. The albumin/creatinine ratio (ACR) is increased in db/db mice in comparison to control mice by 7.1 fold and Olmesartan treatment significantly decreases ACR by 59% in db/db mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 144689-63-4
• MW: 558.5851
• Purity: >98% (HPLC)
• Formula: C₂₉H₃₀N₆O₆
• SMILES: O=C(C1=C(C(C)(O)C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)OCC5=C(C)OC(O5)=O
• Target: Angiotensin Receptor
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CS-866

Quick Database Links

Gene Symbol

Angiotensin Receptor