Olesoxime

SKU: orb1299645

Description

Olesoxime (TRO19622) is an investigational neuroprotective small molecule that targets mitochondria. It has demonstrated protective effects in preclinical models of neurodegenerative diseases, including in vitro studies on neuronal cells and in vivo research in animal models of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).

Research Area

Metabolism Research

Key Properties

• CAS Number: 22033-87-0
• MW: 399.65
• Purity: 99.86% (May vary between batches)
• Formula: C₂₇H₄₅NO
• SMILES: CC(C)CCC[C@H](C)[C@@H]1CC[C@@H]2[C@H]3CCC4=CC(CC[C@@]4(C)[C@@H]3CC[C@@]12C)=NO
• Target: Mitochondrial Metabolism
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5 mM);DMSO:51 mg/mL (127.61 mM)

Bioactivity

• In Vivo:
  Olesoxime, a molecule from a novel "cholesterol-oxime" family of cytoprotective compounds identified based on survival promoting activities on trophic factor deprived motor neurons shows neuroprotective and neuroregenerative effects in five animal models of motor nerve degeneration.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mitochondrial Metabolism, MitochondrialMetabolism, Olesoxime, inhibit, Inhibitor, NSC 21311, NSC-21311, NSC21311, TRO 19622, TRO19622, TRO-19622

Compound Identifiers

PubChem CID

57369604