Octenidine Dihydrochloride

SKU: orb1304344

Description

Octenidine is a synthetic antimicrobial compound used in research. It is applied in studies of topical antiseptics, biofilm disruption, and wound healing models, with utility in both in vitro microbiological assays and in vivo preclinical infection research.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70775-75-6
• MW: 623.82
• Purity: 99.11% (May vary between batches)
• Formula: C₃₆H₆₄Cl₂N₄
• SMILES: [Cl-].[Cl-].CCCCCCCCNc1cc[n+](CCCCCCCCCC[n+]2ccc(NCCCCCCCC)cc2)cc1
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:9.62 mg/mL (15.42 mM);H2O:50 mg/mL (80.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.6 mM)

Bioactivity

• In Vivo:
  Octenidine hydrochloride (OCT) demonstrates sustained antimicrobial activity upon application to the skin of cynomolgus monkeys' hands and feet. Aqueous octenidine effectively diminishes resident microflora by 90 to 99.98% at concentrations ranging from 0.2 to 1.6%. Moreover, a significant reduction in plaque score on buccal tooth surfaces was observed following daily topical applications of 1% solutions of octenidine and chlorhexidine for seven days, with octenidine proving to be more effective than chlorhexidine.
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• In Vitro:
  Octenidine at concentrations below 1.5 μM (0.94 μg/mL) results in over 99% reduction of the assessed microbial population within 15 minutes. Among the tested organisms, Staphylococcus epidermidis exhibits the highest susceptibility, whereas E. coli and C. Albicans show the lowest susceptibility.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, Inhibitor, inhibit, Octenidine, Octenidine Dihydrochloride

Compound Identifiers

PubChem CID

198481