Ochromycinone

SKU: orb1300277

Description

Ochromycinone

Research Area

Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 111540-00-2
• MW: 306.31
• Purity: 99.21%
• Formula: C₁₉H₁₄O₄
• SMILES: CC1CC(=O)c2c(C1)ccc1C(=O)c3c(O)cccc3C(=O)c21
• Target: Antibacterial,STAT,Antibiotic
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:20 mg/mL (65.29 mM);Ethanol:2 mg/mL (6.53 mM);10% DMSO+90% Corn Oil:1.5 mg/mL (4.9 mM)

Bioactivity

• In Vivo:
  In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.
• In Vitro:
  In cells, Ochromycinone inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. Ochromycinone remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, Ochromycinone also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.
• Cell Research:
  Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STAT, STA 21, STA21, STA-21, STAT3, inhibit, Ochromycinone, Inhibitor, DNA, dimerization, antibiotic, antimicrobial, anticancer, Bacterial, binding

Compound Identifiers

PubChem CID

363709