O-Desmethyl dacomitinib

SKU: orb3175049

Description

O-Desmethyl dacomitinib (PF-05199265) is the primary circulating metabolite of Dacomitinib and acts as a pan-ErbB tyrosine kinase inhibitor, targeting epidermal growth factor receptors. The exposure level of O-Desmethyl dacomitinib is significantly lower than that of Dacomitinib, and its formation is highly dependent on CYP2D6 enzyme activity.

Images & Validation

−

Key Properties

−

CAS Number	2468202-15-3
MW	455.92
Formula	C₂₃H₂₃ClFN₅O₂
SMILES	N(C=1C2=C(C=C(O)C(NC(/C=C/CN3CCCCC3)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4
Target	EGFR,Drug Metabolite

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

EGFR,Drug Metabolite

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols