Nystatin

SKU: orb1307781

Description

Nystatin (Fungicidin) is an orally active polyene antibiotic effective against yeast and mycoplasma. It is widely used in research to study antifungal mechanisms and to treat models of cutaneous and oropharyngeal candidiasis in both in vitro and in vivo experimental settings.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1400-61-9
• MW: 926.1
• Purity: 69.55% (May vary between batches)
• Formula: C₄₇H₇₅NO₁₇
• SMILES: C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\CC\C=C\C=C\C=C\C=C\2)[C@@H](O)[C@@H](N)[C@@H]1O
• Target: Antifungal,Apoptosis,Antibacterial,Antibiotic
• Solubility: DMSO:250 mg/mL;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL

Bioactivity

• Target IC50:
  Wuhan strain:62.5 μg/ml|Fungus:19.6 μg/mL|British mutant:125 μg/ml
• In Vivo:
  Nystatin combined with endostatin selectively enhances endostatin uptake and biodistribution in tumor blood vessels and tumor tissues rather than in normal tissues of tumor-bearing mice, ultimately leading to elevated antiangiogenic and antitumor efficacies of endostatin in vivo. Liposomal Nystatin, at doses as low as 2 mg/kg of body weight/day, protects neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group.
• In Vitro:
  METHODS: Hippocampal neurons were treated with Nystatin (2.5-25 µM) for 30 min and cell morphology was examined. RESULTS: Acute incubation with different concentrations of Nystatin increased the growth cone size of hippocampal neurons. METHODS: CHO cells were treated with Nystatin (100-300 µmol/L) for 10-60 min, and cell viability was measured by MST-1 assay. RESULTS: Cell viability studies after Nystatin application showed significant concentration- and time-dependent effects. At Nystatin concentrations equal to 100 µmol/L, the percentage of viable cells was significantly higher compared to higher concentrations.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fungal, Fungicidin, inhibit, Inhibitor, Nystatin, Nystavescent, Apoptosis, Antifungal, Antibiotic, Stamycin

Compound Identifiers

PubChem CID

155859161