NXPZ-2

SKU: orb1685826

Description

NXPZ-2 is a potent, orally bioavailable small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction (Ki: 95 nM). It demonstrates efficacy in Alzheimer's disease mouse models, reducing Aβ-induced cognitive deficits and neuropathology, making it a valuable research tool for studying Nrf2 pathway modulation in neurodegenerative disorders.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2254492-08-3
• MW: 597.66
• Formula: C₂₇H₂₇N₅O₇S₂
• SMILES: N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC(N)=O)C=2C3=C(C(N(S(=O)(=O)C4=CC=C(N)C=C4)CC(N)=O)=CC2)C=CC=C3
• Target: Others,Nrf2

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164513524