NT160

SKU: orb2278464

Description

NT160 is a fluorinated, radioactive small molecule that acts as a potent and selective class IIa histone deacetylase (HDAC) inhibitor. It is a valuable research tool for investigating epigenetic mechanisms in neurological disease models, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1418293-40-9
• MW: 418.41
• Formula: C₂₁H₂₁F₃N₄O₂
• SMILES: C(F)(F)(F)C1=NC(=NO1)C2=CC=C(C(N[C@@H](CN(CC3=CC=CC=C3)C)C)=O)C=C2
• Target: HDAC
• Solubility: DMSO:80 mg/mL (191.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.89 mM)

Bioactivity

• Target IC50:
  HDAC9:0.9 nM|HDAC7:1.0 nM|HDAC5:1.2 nM|HDAC4:0.08 nM
• In Vivo:
  NT160 was able to penetrate the blood-brain barrier and accumulate in the brains of mice.
• In Vitro:
  NT160 is a highly effective Class IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 showed very high inhibition on HDAC4, HDAC5, HDAC7 and HDAC9, with IC50 values of 0.08 nM, 1.2 nM, 1.0 nM and 0.9 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NT 160

Compound Identifiers

PubChem CID

71230992