NT1-20

• Catalog Number: orb1140586
• Category: Proteins
• Description: Blocks ASIC1a binding to RIPK1; Cell penetrating peptides.
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 3655.22 Da
• Formula: C₁₅₀H₂₆₅N₅₅O₄₇S₂
• Structure: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Met-Glu-Leu-Lys-Thr-Glu-Glu-Glu-Glu-Val-Gly-Gly-Val-Gln-Pro-Val-Ser-Ile-Gln-Ala-OH
• Solubility (25°C): Soluble in water
• Protein Sequence: GRKKRRQRRRCMELKTEEEEVGGVQPVSIQA
• Storage: Store dry, frozen and in the dark
• Alternative names: GRKKRRQRRRCMELKTEEEEVGGVQPVSIQA, NT1-20, NT1-20 ,
• Background: NT1-20 is a tatylated membrane penetrating peptide derived from the N-terminus of the acid sensing ion channel 1a (ASIC1a), which can block ASIC1a binding receptor interacting protein kinase 1 (RIPK1) to its C terminus. ASIC1a mediates necroptosis via recruiting RIPK1, independent of its ion-conducting function, and though this mechanism NT1-20 can protect neurons against acidosis induced necroptosis in vitro. NT1-20 can also reduce neuronal damage in mousemodels of ischemic stroke.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.