NSC16168

SKU: orb1706902

Description

NSC16168

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 6837-93-0
• MW: 473.5
• Purity: 99.88% (May vary between batches)
• Formula: C₁₇H₁₅NO₉S₃
• SMILES: O=S(=O)(O)C=1C=C(OS(=O)(=O)C2=CC=C(C=C2)C)C3=C(N)C=C(C=C3C1)S(=O)(=O)O
• Target: Others,DNA/RNA Synthesis,DNA
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM);DMSO:20 mg/mL (42.24 mM)

Bioactivity

• Target IC50:
  ERCC1 XPF:0.42 μM
• In Vivo:
  In the H460 lung cancer xenograft model, NSC16168 was injected intraperitoneally twice a day at a dose of 20 mg/kg and showed significant antitumor effects and synergistically enhanced the efficacy of cisplatin.
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• In Vitro:
  NSC16168 is a specific inhibitor of ERCC1-XPF with an IC50 of 0.42 μM. NSC16168 potentiates the antitumor effect of cisplatin on cancer cells in the concentration range of 0-50 μM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERCC1-XPF, EstrogenReceptor, Estrogen Receptor, NSC 16168, NSC16168, NSC-16168, progestogen Receptor, progestogenReceptor

Compound Identifiers

PubChem CID

23270