NS9283

SKU: orb1304978

Description

NS9283

Research Area

Neuroscience

Key Properties

• CAS Number: 913830-15-6
• MW: 248.24
• Purity: 99.12%
• Formula: C₁₄H₈N₄O
• SMILES: C(#N)C=1C=C(C2=NC(=NO2)C=3C=CC=NC3)C=CC1
• Target: AChR
• Solubility: DMSO:3.06 mg/mL (12.33 mM)

Bioactivity

• In Vivo:
  In Male and f Male C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss o the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake In both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversio.
• In Vitro:
  NS9283 increase the potency of varenicline to activate and desensitize α4β2 nAChRs in vitro without affecting Other known targets of vareniclin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

nAChR, Nicotinic acetylcholine receptors, Inhibitor, inhibit, NS 9283, NS9283, NS-9283, α4β2 nAChR

Compound Identifiers

PubChem CID

11998180