NS5806

SKU: orb1307946

Description

NS5806 is a small molecule activator of potassium currents that modulates KV4.3 and KV4.2 channels, particularly in complexes with KChIP2. It slows current decay and increases peak current amplitude (EC50 ~5.3 μM). This tool compound is used in vitro to study cardiac transient outward potassium current (Ito) and neuronal A-type currents.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 426834-69-7
• MW: 574.07
• Purity: 99.63% (May vary between batches)
• Formula: C₁₆H₈Br₂F₆N₆O
• SMILES: FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c2nn[nH]n2)cc(c1)C(F)(F)F
• Target: Potassium Channel
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (5.75 mM);DMSO:250 mg/mL (435.49 mM)

Bioactivity

• Target IC50:
  Kv4.3/KChIP2 channel:5.3 μM
• In Vitro:
  NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dacay, current, amplitudes, inhibit, KChIP2, Inhibitor, KcsA, KV4.2, KV4.3, NS 5806, NS5806, NS-5806, Ito, peak, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

11642685