NS3623

SKU: orb1307947

Description

NS3623 is a dual-action small molecule that both activates and inhibits the human ether-à-go-go-related gene (hERG) potassium channel. It modulates IKr and Ito currents, exhibiting antiarrhythmic properties useful for in vitro electrophysiology studies and cardiovascular research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 343630-41-1
• MW: 427.18
• Purity: 98.10%
• Formula: C₁₅H₁₀BrF₃N₆O
• SMILES: FC(F)(F)c1cccc(NC(=O)Nc2ccc(Br)cc2-c2nnn[nH]2)c1
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.34 mM);DMSO:9.17 mg/mL (21.47 mM)

Bioactivity

• In Vivo:
  NS3623 (30 mg/kg; i.v.; lasting for 3 minutes) shortens the corrected QT interval by 25 ± 4% in anaesthetized guinea pigs. At 50 mg/kg, NS3623 immediately reduces the QTcF interval and remains significantly shortened for approximately 30 minutes, also shortening the QT interval by 30 ± 6% in conscious guinea pigs .
• In Vitro:
  Administering NS3623 (5 μM) significantly enhances the tail current magnitude in isolated canine cardiomyocytes, corroborating earlier evidence that this compound augments IKr. Specifically, NS3623 boosts IKr tail currents by 60% in normal Mid cells and by 68% in cells cultured for 48 hours, at a +50 mV activating pulse. Furthermore, although the baseline IKr in cells cultured for 48 hours markedly declines compared to freshly isolated cells—from 0.47 ± 0.08 pA/pF to 0.28 ± 0.06 pA/pF—NS3623 application elevates IKr in these cultured Mid cells. An analysis of the current-voltage (I-V) relationship for IKr tail current reveals that NS3623 increases current density in Mid cells cultured for both one and two days.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

canine, Antiarrhythmic, cells, channels, cardiomyocytes, current, midmyocardial, ion, KcsA, inhibit, KV11.1, NS-3623, NS3623, NS 3623, Inhibitor, effect, Potassium, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

9954236