NS 11021

SKU: orb1302978

Description

NS 11021 is a selective pharmacological activator of large-conductance calcium-activated potassium (BK) channels. This research compound is utilized in vitro and in vivo to investigate BK channel function in fields such as neuroprotection, vascular tone regulation, and smooth muscle physiology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 956014-19-0
• MW: 511.24
• Purity: 97.26%
• Formula: C₁₆H₉BrF₆N₆S
• SMILES: FC(F)(F)c1cc(NC(=S)Nc2ccc(Br)cc2-c2nnn[nH]2)cc(c1)C(F)(F)F
• Target: Potassium Channel
• Solubility: DMSO:250 mg/mL (489.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.78 mM)

Bioactivity

• In Vivo:
  NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs. NS11021 reduced [Ca(2+)](i) and tension in penile arteries. IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue. NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, KcsA, KCa1.1, inhibit, NS-11021, NS11021, NS 11021, Inhibitor, Ca2+ channel

Compound Identifiers

PubChem CID

24825677