Notoginsenoside Ft1

SKU: orb1301515

Description

Notoginsenoside Ft1 is a bioactive saponin derived from Panax notoginseng. It is utilized in research for its diverse pharmacological activities, including studies in inflammation, cardiovascular function, and metabolic disorders, as investigated in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 155683-00-4
• MW: 917.13
• Purity: 98.00% (May vary between batches)
• Formula: C₄₇H₈₀O₁₇
• SMILES: [H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@]4([H])OC[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@](C)(O)CCC=C(C)C
• Target: HIF/HIF Prolyl-Hydroxylase,Apoptosis
• Solubility: DMSO:145 mg/mL (158.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.18 mM)

Bioactivity

• In Vitro:
  Notoginsenoside Ft1 (Ft1) is a novel stimulator of angiogenesis. Ft1 induces proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells (HUVECs). Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways. In addition, Ft1 induces phosphorylation of the mammalian target of rapamycin (mTOR), and siRNA-mediated mTOR knockdown decreases tube formation, proliferation, transport of HIF-1α into nuclei and VEGF mRNA expression in response to Ft1.Among the saponins examined, Notoginsenoside Ft1(Ft1) was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HIFProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF ProlylHydroxylase, HIF, Notoginsenoside Ft 1, Notoginsenoside Ft1, Notoginsenoside Ft-1, inhibit

Compound Identifiers

PubChem CID

91973814