NMDAR antagonist 5

SKU: orb3028189

Description

NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3038464-68-2
• MW: 267.369
• Formula: C₁₇H₂₁N₃
• SMILES: [C@]1(CC2=C(CC1)NN=C2)(N3CCCC3)C4=CC=CC=C4
• Target: Dopamine Receptor,Monoamine Transporter,iGluR,Serotonin Transporter

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dopamine Receptor,Monoamine Transporter,iGluR,Serotonin Transporter