NKP608

SKU: orb1679056

Description

NKP608

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 177707-12-9
• MW: 619.99
• Purity: 99.88%
• Formula: C₃₁H₂₄ClF₆N₃O₂
• SMILES: C([C@H]1N(C(=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)CC[C@H](NC(=O)C=3C4=C(N=CC3)C=CC=C4)C1)C5=CC=C(Cl)C=C5
• Target: Neurokinin receptor
• Solubility: DMSO:80 mg/mL (129.03 mM);H2O:Insoluble.;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.32 mM)

Bioactivity

• Target IC50:
  HSP:13 nM (gerbil midbrain)|HSP:27 nM (rat striatum)|HSP:2.6 nM (bovine retina)|IP1:2.6 nM
• In Vivo:
  NKP608 (0.03, 0.1, 0.3, 1 or 3 mg/kg) was given orally 2, 5 or 24 h prior to the i.c.v. administration of 1 mg SPOMe. NKP608 dose-dependently attenuated SPOMe-induced hind foot thumping.
• In Vitro:
  NKP608 inhibited the binding of H-SP to bovine retina with an IC50 of 2.6 nM, and to rat striatum and gerbil midbrain membranes with IC50s of 27 and 13 nM. In human astrocytoma cell (U-373) cultures NKP608 inhibited the SP induced increase in IP1 accumulation with an IC50 of 2.6 nM, indicating potent functional antagonism at the human receptor.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neurokininreceptor, Neurokinin receptor, Neurokinin Receptor, NKP608, NKP-608, NKP 608, NK-1

Compound Identifiers

PubChem CID

9917079