Nitecapone

SKU: orb1299466

Description

Nitecapone

Research Area

Metabolism Research

Key Properties

• CAS Number: 116313-94-1
• MW: 265.22
• Purity: 98.39% (May vary between batches)
• Formula: C₁₂H₁₁NO₆
• SMILES: CC(=O)C(=Cc1cc(O)c(O)c(c1)[N+]([O-])=O)C(C)=O
• Target: Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.77 mM);DMSO:2.5 mg/mL (9.43 mM)

Bioactivity

• Target IC50:
  S-COMT:300 nM
• In Vivo:
  After single administration, both nitecapone and OR-486 reduced mechanical nociceptive thresholds and thermal nociceptive latencies (hot plate test) at 2 and 3 h, regardless of their brain penetration. These effects were still present after chronic treatment with COMT inhibitors for 5 days. Intraplantar injection of carrageenan reduced nociceptive latencies and both COMT inhibitors potentiated this reduction without modifying inflammation. CGP 28014 shortened paw flick latencies. OR-486 did not modify hot plate times in Comt gene deficient mice. Intrathecal nitecapone modified neither thermal nor mechanical nociception.
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• In Vitro:
  At high micromolar to millimolar concentrations in in vitro research studies, nitecapone is an effective antioxidant, nitric oxide radical scavenger, and iron chelator that can protect cells from lipid peroxidation
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• Animal Research:
  Used single and repeated administration of a peripherally restricted, short-acting (nitecapone) and also a centrally acting (3,5-dinitrocatechol, OR-486) COMT inhibitor. We also tested CGP 28014, an indirect inhibitor of COMT enzyme. Effects of OR-486 on thermal nociception were also studied in COMT deficient mice. Effects on spinal pathways were assessed in rats given intrathecal nitecapone.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, S-COMT, inhibit, OR 462, OR462, OR-462, Nitecapone, Parkinson, Inhibitor, glutathione, GSH, allodynia, COMT

Compound Identifiers

PubChem CID

5464105