Nilvadipine

SKU: orb1308664

Description

Nilvadipine

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 75530-68-6
• MW: 385.37
• Purity: 99.93%
• Formula: C₁₉H₁₉N₃O₆
• SMILES: C(OC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C#N)C2=CC(N(=O)=O)=CC=C2
• Target: Calcium Channel
• Solubility: Ethanol:19.3 mg/mL (50.08 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (6.49 mM);DMSO:55 mg/mL (142.72 mM)

Bioactivity

• Target IC50:
  Ca2+ channel:0.03 nM
• In Vivo:
  In perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor.
• In Vitro:
  In RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARC 029, ARC029, ARC-029, Calcium Channel, Ca channels, Ca2+ channels, CalciumChannel, Inhibitor, FR34235, FR-34235, FR 34235, FK235, FK-235, FK 235, Nilvadipine, inhibit

Compound Identifiers

PubChem CID

4494