Nilvadipine

SKU: orb1308664

Description

Nilvadipine

Research Area

Neuroscience

Key Properties

• CAS Number: 75530-68-6
• MW: 385.38
• Purity: >98%
• Formula: C₁₉H₁₉N₃O₆
• SMILES: C(OC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C#N)C2=CC(N(=O)=O)=CC=C2
• Target: Kinase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  Ca2+ channel:0.03 nM
• In Vivo:
  In perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor.
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• In Vitro:
  In RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FR34235

Compound Identifiers

PubChem CID

4494