Nifurpirinol

SKU: orb1983235

Description

Nifurpirinol is an antimicrobial agent with acute toxicity in milkfish (Chanos chanos). It is used in research to selectively inhibit collagen production, as demonstrated in zebrafish models like the Fli//colRN line, making it a tool for studying tissue development and antimicrobial mechanisms in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 13411-16-0
• MW: 246.22
• Purity: 99.70% (May vary between batches)
• Formula: C₁₂H₁₀N₂O₄
• SMILES: O=[N+]([O-])C1=CC=C(/C=C/C2=CC=CC(CO)=N2)O1
• Target: Antibacterial,Topoisomerase,Antibiotic
• Solubility: DMSO:10 mg/mL (40.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.06 mM)

Bioactivity

• In Vivo:
  Strong hyperglycemia was detected in fish treated with Nifurpirinol (523 ±113 mg/dl, n=8) as compared to control fish (65 ±13 mg/dl, n=9). This indicates that NFP is able to induce pancreatic beta cell ablation and thus acts as a substrate for NTR-mediated cell ablation.
• In Vitro:
  Nifurpirinol-treated larvae show more cell debris and large CFP+ cells with a large cytoplasm and irregular nucleus which are presumably phagocytic cells having engulfed apoptotic CFP neurons. Furthermore, Nifurpirinol-treated larvae display much fewer cells with a normal morphology as compared to MTZ treated larvae, underpinning a more efficient ablation with Nifurpirinol.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antibiotic, Bacterial, P7138, P-7138, P 7138

Compound Identifiers

PubChem CID

6436061