NH2-PEG3-Val-Cit-PAB-OH

SKU: orb3022047

Description

NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Key Properties

• CAS Number: 2055024-62-7
• MW: 582.69
• Formula: C₂₇H₄₆N₆O₈
• SMILES: [C@H](C(NC1=CC=C(CO)C=C1)=O)(NC([C@@H](NC(CCOCCOCCOCCN)=O)[C@@H](C)C)=O)CCCNC(N)=O
• Target: ADC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ADC Linker