NH2-C5-NH-Boc

SKU: orb1307303

Description

PROTAC Linker 23 (NH2-C5-NH-Boc) is an alkyl chain-based chemical spacer utilized in constructing Proteolysis-Targeting Chimeras (PROTACs). This bifunctional linker is essential for connecting an E3 ligase ligand to a target protein ligand, enabling the degradation of specific proteins in biochemical and cellular research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51644-96-3
• MW: 202.29
• Purity: 99.14% (May vary between batches)
• Formula: C₁₀H₂₂N₂O₂
• SMILES: C(NCCCCCN)(OC(C)(C)C)=O
• Target: PROTAC Linker
• Solubility: Ethanol:100 mg/mL (494.34 mM)

Bioactivity

• In Vitro:
  PROTACs consist of two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PROTACLinker, PROTAC Linker, PROTAC Linkers, PROTAC Linker 23, PROTAC Linker23, PROTAC Linker-23, Inhibitor, inhibit, NH2C5NHBoc, NH-2-C5-NH-Boc, NH2-C5-NH-Boc, NH2 C5 NH Boc, Alkyl-Chain

Compound Identifiers

PubChem CID

4352