β-NF-JQ1

SKU: orb1741538

Description

β-NF-JQ1 is a PROTAC molecule that utilizes β-naphthoflavone to engage the AhR E3 ligase, directing it to degrade BRD-containing proteins. This bifunctional degrader demonstrates potent anticancer activity through targeted protein knockdown in cellular studies, making it a valuable tool for probing BRD protein function and PROTAC mechanisms in cancer research.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2380000-55-3
• MW: 816.36
• Purity: 99.15%
• Formula: C₄₅H₄₂ClN₅O₆S
• SMILES: CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC4=CC=C(C=C4)C=5OC=6C(C(=O)C5)=C7C(=CC6)C=CC=C7)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C
• Target: PROTACs,Epigenetic Reader Domain

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD, AhR, b-NF-JQ1, beta-NF-JQ1, PROTAC, β NF JQ1, βNFJQ1, β-NF-JQ1, β-NF-JQ-1

Compound Identifiers

PubChem CID

139600342