Neuropathiazol

SKU: orb1706916

Description

Neuropathiazol is a small molecule that induces the differentiation of adult hippocampal neural progenitor cells into neurons. This compound is a valuable research tool for studying neurogenesis, neural development, and potential therapeutic strategies for neurological disorders in both in vitro and in vivo models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 880090-88-0
• MW: 338.42
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₁₈N₂O₂S
• SMILES: CCOC(=O)C1=CC=C(C=C1)N(C)C1=CSC(=N1)C1=CC=CC=C1
• Target: TGF-beta/Smad,Others
• Solubility: DMSO:50 mg/mL (147.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.91 mM)

Bioactivity

• In Vitro:
  In HCN cells, Neuropathiazol (5, 10, and 15 μM) significantly slows cell proliferation and inhibits the proliferation of HCN neural progenitor cells. Neuropathiazol (10 μM) down-regulates Sox2, up-regulates NeuroD1, and inhibits the differentiation of astroglial induced by LIF and BMP2.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neuropathiazol

Compound Identifiers

PubChem CID

11667240