Nesolicaftor

SKU: orb1307834

Description

Nesolicaftor (PTI-428) is a CFTR amplifier that increases the production of the cystic fibrosis transmembrane conductance regulator protein. It is utilized in research to investigate CFTR biology and has been evaluated in both cellular assays and clinical studies for cystic fibrosis.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1953130-87-4
• MW: 354.36
• Purity: 99.79% (May vary between batches)
• Formula: C₁₈H₁₈N₄O₄
• SMILES: C[C@@H](O)c1nnc(o1)[C@H]1C[C@@H](C1)NC(=O)c1cc(no1)-c1ccccc1
• Target: Autophagy,CFTR
• Solubility: DMSO:100 mg/mL (282.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.29 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, cystic fibrosis, Cystic fibrosis transmembrane conductance regulator, CFTR, Inhibitor, inhibit, Nesolicaftor, PTI 428, PTI428, PTI-428

Compound Identifiers

PubChem CID

121439966