Nervonic acid

SKU: orb1221353

Description

Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin. It consists of choline sphingosine phosphoric acid and fatty acid. Nervonic acid may enhance the brain functions and prevent demyelination (Chemical Land21). Research shows that there is negative relationship between nervonic acid and obesity-related risk factors. Demyelination in adrenoleukodystrophy (ALD) is associated with an accumulation of very long chain saturated fatty acids stemming from a genetic defect in the peroxisomal beta oxidation system responsible for the chain shortening of these fatty acids. Sphingolipids from post mortem ALD brain have decreased levels of nervonic acid 24:1(n-9) and increased levels of stearic acid 18:0.

Key Properties

• CAS Number: 506-37-6
• MW: 366.62
• Purity: >98% (HPLC)
• Formula: C₂₄H₄₆O₂
• SMILES: CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO:10 mM;Water:1mg/mL

Bioactivity

• In Vivo:
  Animal model: MPTP-induced PD mice model. Dosage: 20, 40, 60 mg/kg. Administration: i. g. Result: Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response. Animal model: DSS-induced colitis mice model. Dosage: 5, 50, 100 mg/kg. Administration: i. g. Result: Improved the symptoms of diarrhea, weight loss and fecal occidental blood. Reduced the levels of COX-2 and iNOS.
• In Vitro:
  Cell Viability Assay Cell line: PC-12. Concentration: 0.001, 0.01, 0.1, 1. 10 μM Incubation time: 48 h. Result: Increased cell viability pretreated with a very low concentration. Western blot analysis. Cell line: RAW264.7 Concentration: 12.5, 25, 50 μM Incubation time: 24 h. Result: Decreased the expression of TLR4, JNK, P38 and NF-κB.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cis-15-Tetracosenoic acid | Selacholeic acid

Quick Database Links

Gene Symbol

Endogenous Metabolite