(-)-Neplanocin A

SKU: orb2283735

Description

(−)-Neplanocin A is a potent, irreversible inhibitor of SAH hydrolase (Ki=8.39 nM), leading to SAH accumulation and inhibition of SAM-dependent methyltransferases. It demonstrates significant antitumor activity against L1210 leukemia cells and broad-spectrum antiviral efficacy, notably against vesicular stomatitis virus, surpassing the potency of reversible analogs like 3-deazaneplanocin.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 72877-50-0
• MW: 263.3
• Formula: C₁₁H₁₃N₅O₃
• SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)C=C(CO)[C@H]1O
• Target: Antibiotic,Virus Protease,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

72968