Nepetin

SKU: orb1297523

Description

Nepetin

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 520-11-6
• MW: 316.26
• Purity: 99.97%
• Formula: C₁₆H₁₂O₇
• SMILES: COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
• Target: Histamine Receptor,Interleukin,Calcium Channel
• Solubility: DMSO:140 mg/mL (442.67 mM);10% DMSO+90% Saline:1 mg/mL (3.16 mM)

Bioactivity

• In Vitro:
  Usin the human basophilic KU812F cells, we assesse the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcαμRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcαμRI ± chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+ i in a dose-dependent manner. Moreover the inhibitory effects of 6-Methoxyluteolin o the cell surfacee expression an the mRNA level o the FcαμRI ± chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, 6-Methoxyluteolin, Calcium Channel, HistamineReceptor, Histamine Receptor, Inhibitor, inhibit, Nepetin

Compound Identifiers

PubChem CID

5317284