Neosmitilbin

SKU: orb1297272

Description

Neosmitilbin (Neoastilbin) is a small molecule exhibiting antioxidant and anti-inflammatory properties. It acts as a potent inhibitor of aldose reductase, making it a candidate for research into diabetic complications, including in vitro studies on cataract formation and metabolic pathways.

Key Properties

• CAS Number: 54081-47-9
• MW: 450.39
• Purity: 99.94%
• Formula: C₂₁H₂₂O₁₁
• SMILES: C[C@@H]1O[C@@H](O[C@H]2[C@@H](Oc3cc(O)cc(O)c3C2=O)c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
• Target: Others
• Solubility: DMSO:55 mg/mL (122.12 mM)

Bioactivity

• In Vitro:
  Phenolic-enriched extract of S. glabra (PEESG) was extracted with 70% ethanol and purified by HP-20 column chromatography. Its antioxidant and anti-inflammatory activities were evaluated by radical scavenging assay, reducing power determination, and lipopolysaccharide (LPS)-induced RAW264.7 cells assays, respectively. PEESG exhibited obviously scavenging capacity for DPPH and ABTS radicals, as well as significant reducing power for ferric ion. Particularly, PEESG (12.5 50 μg/mL) showed a significantly higher efficiency for scavenging ABTS than that of ascorbic acid and no significant difference with ascorbic acid for DPPH scavenging. PEESG also possessed a significant suppression effect on proinflammatory mediators production, such as nitric oxide (NO), tumor necrosis factor- α± (TNF- α± ), and interleukin-6 (IL-6), in LPS-induced RAW264.7 cells. In addition, the main ingredients of PEESG were identified using ultrahigh pressure liquid chromatography coupled to electrospray mass spectrometry (U-HPLC-ESI-MS). Seventeen components, including 5-O-caffeoylshikimic acid, Neoastilbin, astilbin, neoisoastilbin, isoastilbin, engetin and isoengeletin were identified.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Neoastilbin, Neosmitilbin

Compound Identifiers

PubChem CID

442437