Nedocromil

SKU: orb1307974

Description

Nedocromil

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 69049-73-6
• MW: 371.34
• Purity: 97.34%
• Formula: C₁₉H₁₇NO₇
• SMILES: CCCc1c2oc(cc(=O)c2cc2c1n(CC)c(cc2=O)C(O)=O)C(O)=O
• Target: Prostaglandin Receptor,Leukotriene Receptor,Histamine Receptor
• Solubility: DMSO:1 mg/mL (2.69 mM)

Bioactivity

• Target IC50:
  PGD2:1.9 μM(IC30)|LTC4:2.3 μM(IC30)|Histamine:2.1 μM(IC30)
• In Vivo:
  Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice .
• In Vitro:
  Nedocromil suppresses the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively. It also has anti-human IgE with IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Prostaglandin Receptor, prostaglandin D2 receptor, ProstaglandinReceptor, PGD2, inhibit, LTC4, Nedocromil, Inhibitor, HistamineReceptor, Histamine, Histamine Receptor, LeukotrieneReceptor, leukotriene C4 (LTC4), Leukotriene Receptor, FPL59002, FPL-59002, FPL 59002

Compound Identifiers

PubChem CID

50294